In this issue of Photonics Focus, we look toward boundaries—real, imagined, and theoretical. One feature explores the heady physics playground of optical skyrmions, fascinating abstractions with real-world potential particularly for quantum technologies. Another feature peers inside the secret life of fallopian tubes. New optics technologies have revealed key insights into women's health and reproduction. Finally, a third feature explores the development of super resolution fluorescence microscopy, or SRM, which required the near impossible: surpassing the diffraction limit.